Supporting clinical data
(1) Phototherapy clinical studies
Regulation of skin collagen metabolism in vitro using a pulsed 660 nm LED light source: clinical correlation with a single-blinded study. Barolet D., Roberge C.J., Auger F.A., Boucher A., and Germain L. (2009). J. Invest. Dermatol. 129, 2751–2759
A prospective, randomized, placebo-controlled, double-blinded, and split-face clinical study on LED phototherapy for skin rejuvenation: Clinical, profilometric, histologic, ultrastructural, and biochemical evaluations and comparison of three different treatment settings. Lee S.Y., Park K.H., Choi J.W., et al. (2007). J. Photochem. Photobiol. B. 88, 51–67
cDNA microarray analysis of gene expression profiles in human fibroblast cells irradiated with red light. Zhang Y., Song S., Fong C.C., et al. (2003). J. Invest. Dermatol. 120, 849–857
(2) Acoustic wave studies
Fibroblast traction as a mechanism for collagen morphogenesis- Nature. 1981 Mar 19;290(5803):249-51; Equibiaxial cyclic stretch stimulates fibroblasts to rapidly remodel fibrin – J Biomech . 2006;39(16):2983-90
Effects of a skin-massaging device on the ex-vivo expression of human dermis proteins and in-vivo facial wrinkles – PLoS One. 2017; 12(3): e0172624.
(3) Skincare studies on Argireline and Matrixyl 3000
The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study. Yuan Wang, Mei Wang, Shengxiang Xiao, Ping Pan, Ping Li, Jia Huo (2013) Am J Clin Dermatol . 2013 Apr;14(2):147-53.
Enhanced Skin Permeation of Anti-wrinkle Peptides via Molecular Modification. Seng Han Lim et al. Sci Rep. 2018; 8: 1596.
Skin rejuvenation using cosmetic products containing growth factors, cytokines, and matrikines: a review of the literature. Caroline Aldag et al. Clin Cosmet Investig Dermatol. 2016; 9: 411–419.
Efficacy of anti-aging products for periorbital wrinkles as measured by 3-D imaging. Kaczvinsky, J.R.; Griffiths, C.E.; Schnicker, M.S.; Li, J.J. Cosmet. Dermatol. 2009, 8, 228–233
(4) Nutraceutical studies
Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta-analysis. Roseane B. de Miranda MD, Patrícia Weimer MD, Rochele C. Rossi PhD
20 March 2021 https://doi.org/10.1111/ijd.15518
A randomized, triple-blind, placebo-controlled, parallel study to evaluate the efficacy of a freshwater marine collagen on skin wrinkles and elasticity
Malkanthi Evans DVM, PhD, Erin D. Lewis PhD, Nisrine Zakaria PhD, Tetyana Pelipyagina MD, Najla Guthrie BSc 16 August 2020 https://doi.org/10.1111/jocd.13676
Anti-aging potential of fish collagen hydrolysates subjected to simulated gastrointestinal digestion and Caco-2 cell permeation. Je HJ, Han YK, Lee HG, Bae IY. J Appl Biol Chem. 2019;62:101–107.
Skin antiageing and systemic redox effects of supplementation with marine collagen peptides and plant-derived antioxidants: A single-blind case-control clinical study. De Luca C1, Mikhal’chik EV, Suprun MV, Papacharalambous M, Truhanov A, Korkina LG. Oxid Med Cell Longev. 2016;2016(4389410) doi: 10.1155/2016/4389410.